Sex Differences in the Systemic and Local Immune Response of Pancreatic Cancer Patients.

ABSTRACT:

Background

Mounting evidence suggests that sex plays a critical role in various aspects of cancer such as immune responses. However, a male bias exists in human and non-human studies including immunotherapy trials. The role of sex on immune responses in pancreatic ductal adenocarcinoma (PDA) is unclear.

Methods

Here, tumor tissues (tumor and stroma separately) and corresponding blood samples from patients with PDA (n = 52) were systematically analyzed by immunohistochemistry and multiplex cytokine measurements and compared by sex.

Results

Females showed a stronger systemic immune response with higher levels of CXCL9, IL1B, IL6, IL10 and IL13. Additionally, more peripheral white blood cells were detected in females. In the microenvironment, males showed higher t

SUBMITTER: Ahmed A 

PROVIDER: S-EPMC10047039 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature