Brain Vascular Health in ALS Is Mediated through Motor Cortex Microvascular Integrity.

ABSTRACT: Brain vascular health appears to be critical for preventing the development of amyotrophic lateral sclerosis (ALS) and slowing its progression. ALS patients often demonstrate cardiovascular risk factors and commonly suffer from cerebrovascular disease, with evidence of pathological alterations in their small cerebral blood vessels. Impaired vascular brain health has detrimental effects on motor neurons: vascular endothelial growth factor levels are lowered in ALS, which can compromise endothelial cell formation and the integrity of the blood-brain barrier. Increased turnover of neurovascular unit cells precedes their senescence, which, together with pericyte alterations, further fosters the failure of toxic metabolite removal. We here provide a comprehensive overview of the pathogenesis of

SUBMITTER: Schreiber S 

PROVIDER: S-EPMC10047140 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature