Biology of Cancer-Testis Antigens and Their Therapeutic Implications in Cancer.

ABSTRACT: Tumour-specific antigens have been an area of interest in cancer therapy since their discovery in the middle of the 20th century. In the era of immune-based cancer therapeutics, redirecting our immune cells to target these tumour-specific antigens has become even more relevant. Cancer-testis antigens (CTAs) are a class of antigens with an expression specific to the testis and cancer cells. CTAs have also been demonstrated to be expressed in a wide variety of cancers. Due to their frequency and specificity of expression in a multitude of cancers, CTAs have been particularly attractive as cancer-specific therapeutic targets. There is now a rapid expansion of CTAs being identified and many studies have been conducted to correlate CTA expression with cancer and therapy-resistant phenotypes. Fu

SUBMITTER: Nin DS 

PROVIDER: S-EPMC10047177 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature