MicroRNA-155 and Disease-Related Immunohistochemical Parameters in Cutaneous Melanoma.

ABSTRACT: Cutaneous melanoma is a severe and life-threatening form of skin cancer with growing incidences. While novel interventions have improved prognoses for these patients, early diagnosis of targeted treatment remains the most effective approach. MicroRNAs have grown to good use as potential biomarkers for early detection and as targets for treatment. miR-155 is well-studied for its role in tumor cell survival and proliferation in various tissues, although its role in melanoma remains controversial. In silico data analysis was performed in the dbDEMC v.3 to identify differentially expressed miRNA. We validated gene targets in melanoma using TarBase v8.0 and miRPath v3.0 and determined protein-protein interactions of the target genes. One hundred forty patients (age range 21-90 years) with cutan

SUBMITTER: Fawzy MS 

PROVIDER: S-EPMC10047208 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature