Performance of VIDAS^® Diagnostic Tests for the Automated Detection of Dengue Virus NS1 Antigen and of Anti-Dengue Virus IgM and IgG Antibodies: A Multicentre, International Study.

ABSTRACT: Dengue is a serious mosquito-transmitted disease caused by the dengue virus (DENV). Rapid and reliable diagnosis of DENV infection is urgently needed in dengue-endemic regions. We describe here the performance evaluation of the CE-marked VIDAS^® dengue immunoassays developed for the automated detection of DENV NS1 antigen and anti-DENV IgM and IgG antibodies. A multicenter concordance study was conducted in 1296 patients from dengue-endemic regions in Asia, Latin America, and Africa. VIDAS^® dengue results were compared to those of competitor enzyme-linked immunosorbent assays (ELISA). The VIDAS^® dengue assays showed high precision (CV ≤ 10.7%) and limited cross-reactivity (≤15.4%) with other infections. VIDAS^® DENGUE NS1 Ag showed high positive an

SUBMITTER: Versiani AF 

PROVIDER: S-EPMC10047366 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature