Systemic Inflammation Indices and Association with Prostate Cancer Survival in a Diverse Patient Cohort.

ABSTRACT: There is a lack of investigations assessing the performance of systemic inflammation indices as outcome predictive tools in African Americans with prostate cancer. This study aims to assess the relationships between neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation (SII), and systemic inflammation response index (SIRI) with survival outcomes among 680 diverse men with prostate cancer. Routine blood results were collected from self-identified African American and European American patients. We applied multivariable Cox regression modeling to examine the associations of systemic inflammation indices with overall and prostate cancer-specific survival. The median survival follow-up was 5.9 years, with 194 deaths. NLR, SII, and SIRI, but not

SUBMITTER: Bailey-Whyte M 

PROVIDER: S-EPMC10047449 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature