Interobserver variability in interim PET assessment in Hodgkin lymphoma-reasons and solutions.

ABSTRACT:

Introduction

Interim PET (iPET) assessment is important for response adaptation in Hodgkin lymphoma (HL). The current standard for iPET assessment is the Deauville score (DS). The aim of our study was to evaluate the causes of interobserver variability in assigning the DS for iPET in HL patients and to make suggestions for improvement.

Methods

All evaluable iPET scans from the RAPID study were re-read by two nuclear physicians, blinded to the results and patient outcomes in the RAPID trial. The iPET scans were assessed visually according to the DS and, thereafter, quantified using the qPET method. All discrepancies of more than one DS level were re-evaluated by both readers to find the reason for the discordant result.

Results

In 249/441 iPET scans (56%) a concordant

SUBMITTER: Georgi TW 

PROVIDER: S-EPMC10047538 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature