Review article: the role of HSD17B13 on global epidemiology, natural history, pathogenesis and treatment of NAFLD.

ABSTRACT:

Background

Non-alcoholic fatty liver disease (NAFLD) occurs in around a quarter of the global population and is one of the leading causes of chronic liver disease. The phenotypic manifestation and the severity of NAFLD are influenced by an interplay of environmental and genetic factors. Recently, several inactivating variants in the novel 17-Beta hydroxysteroid dehydrogenase 13 (HSD17B13) gene have been found to be associated with a reduced risk of chronic liver diseases, including NAFLD.

Aims

To review the existing literature on the epidemiology of HSD17B13 and discuss its role in the natural history, disease pathogenesis and treatment of NAFLD.

Methods

We extensively searched relevant literature in PubMed, Google Scholar, clinicaltrials.gov and the reference list of

SUBMITTER: Amangurbanova M 

PROVIDER: S-EPMC10047549 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature