Molecular Characterization and Prognosis of Lactate-Related Genes in Lung Adenocarcinoma.

ABSTRACT:

Objective

To explore the lactate-related genes (LRGs) in lung adenocarcinoma (LUAD) by various methods, construct a prognostic model, and explore the relationship between lactate subtypes and the immune tumor microenvironment (TME).

Methods

24 LRGs were collected. The mutation landscape and the prognosis value of LRGs were explored by using The Cancer Genome Atlas (TCGA) data. Consensus clustering analysis was used for different lactate subtype identification. Based on the lactate subtypes, we explore the landscape of TME cell infiltration. A risk-score was calculated by using the LASSO-Cox analysis. A quantitative real-time PCR assay was utilized to validate the expression of characteristic genes in clinical cancer tissues and paracarinoma tissues from LUAD patients.

Res

SUBMITTER: Guo Z 

PROVIDER: S-EPMC10047707 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature