Differential Occupancy and Regulatory Interactions of KDM6A in Bladder Cell Lines.

ABSTRACT: Epigenetic deregulation is a critical theme which needs further investigation in bladder cancer research. One of the most highly mutated genes in bladder cancer is KDM6A, which functions as an H3K27 demethylase and is one of the MLL3/4 complexes. To decipher the role of KDM6A in normal versus tumor settings, we identified the genomic landscape of KDM6A in normal, immortalized, and cancerous bladder cells. Our results showed differential KDM6A occupancy in the genes involved in cell differentiation, chromatin organization, and Notch signaling depending on the cell type and the mutation status of KDM6A. Transcription factor motif analysis revealed HES1 to be enriched at KDM6A peaks identified in the T24 bladder cancer cell line; moreover, it h

SUBMITTER: Ozden-Yılmaz G 

PROVIDER: S-EPMC10047809 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature