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Considerations of the Genetic Background of Obesity among Patients with Psoriasis.


ABSTRACT: Psoriasis comorbidities may emerge from pleiotropic mechanisms, including common proinflammatory pathways, cellular mediators or genetic predisposition. Obesity is considered to be an independent risk factor of psoriasis, which may influence the severity of the disease and its early onset, decrease patients' quality of life, alter response to psoriasis therapies and affect morbidity by reduced life expectancy due to cardiovascular events. Although novel approaches, including genetic techniques, have provided a wide range of new research, there are still scarce studies elaborating on the common genetic background of psoriasis and obesity. The aim of this study was to present and evaluate a possible common genetic background of psoriasis and concomitant increased body mass based on the review of the available literature.

SUBMITTER: Czarnecka A 

PROVIDER: S-EPMC10048146 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature

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Considerations of the Genetic Background of Obesity among Patients with Psoriasis.

Czarnecka Anna A   Purzycka-Bohdan Dorota D   Zabłotna Monika M   Bohdan Michał M   Nowicki Roman J RJ   Szczerkowska-Dobosz Aneta A  

Genes 20230226 3


Psoriasis comorbidities may emerge from pleiotropic mechanisms, including common proinflammatory pathways, cellular mediators or genetic predisposition. Obesity is considered to be an independent risk factor of psoriasis, which may influence the severity of the disease and its early onset, decrease patients' quality of life, alter response to psoriasis therapies and affect morbidity by reduced life expectancy due to cardiovascular events. Although novel approaches, including genetic techniques,  ...[more]

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