Folate-Methionine Cycle Disruptions in ASD Patients and Possible Interventions: A Systematic Review.

ABSTRACT: Autism Spectrum Disorder (ASD) has become a major public health concern due to its rapidly rising incidence over the past few years. Disturbances in folate or methionine metabolism have been identified in many individuals with ASD, suggesting that the folate-methionine cycle may play an essential role in the pathogenesis of autism. Thus, changes in metabolite concentrations associated with this cycle could be used as potential biomarkers and therapeutic targets for ASD. The aim of this systematic review is to elucidate the perturbations of this cycle and the possible interventions that may be proposed in this context. Several studies have shown that high levels of homocysteine and low levels of vitamins B12 and folate are associated with ASD. These changes in serum metabolites are influenc

SUBMITTER: Roufael M 

PROVIDER: S-EPMC10048251 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature