Maternal Epigenetic Dysregulation as a Possible Risk Factor for Neurodevelopmental Disorders.

ABSTRACT: Neurodevelopmental Disorders (NDs) are a heterogeneous group of disorders and are considered multifactorial diseases with both genetic and environmental components. Epigenetic dysregulation driven by adverse environmental factors has recently been documented in neurodevelopmental disorders as the possible etiological agent for their onset. However, most studies have focused on the epigenomes of the probands rather than on a possible epigenetic dysregulation arising in their mothers and influencing neurodevelopment during pregnancy. The aim of this research was to analyze the methylation profile of four well-known genes involved in neurodevelopment (BDNF, RELN, MTHFR and HTR1A) in the mothers of forty-five age-matched AS (Asperger Syndrome), ADHD (Attention Defic

SUBMITTER: Lintas C 

PROVIDER: S-EPMC10048308 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature