Thermo-Responsive Injectable Hydrogels Formed by Self-Assembly of Alginate-Based Heterograft Copolymers.

ABSTRACT: Polysaccharide-based graft copolymers bearing thermo-responsive grafting chains, exhibiting LCST, have been designed to afford thermo-responsive injectable hydrogels. The good performance of the hydrogel requires control of the critical gelation temperature, T_gel. In the present article, we wish to show an alternative method to tune T_gel using an alginate-based thermo-responsive gelator bearing two kinds of grafting chains (heterograft copolymer topology) of P(NIPAM₈₆-co-NtBAM₁₄) random copolymers and pure PNIPAM, differing in their lower critical solution temperature (LCST) about 10 °C. Interestingly, the T_gel of the heterograft copolymer is controlled from the overall hydrophobic content, NtBAM, of both gr

SUBMITTER: Safakas K 

PROVIDER: S-EPMC10048633 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature