Iroquois Family Genes in Gastric Carcinogenesis: A Comprehensive Review.

ABSTRACT: Gastric cancer (GC) is the fifth leading cause of cancer-associated death worldwide, accounting for 768,793 related deaths and 1,089,103 new cases in 2020. Despite diagnostic advances, GC is often detected in late stages. Through a systematic literature search, this study focuses on the associations between the Iroquois gene family and GC. Accumulating evidence indicates that Iroquois genes are involved in the regulation of various physiological and pathological processes, including cancer. To date, information about Iroquois genes in GC is very limited. In recent years, the expression and function of Iroquois genes examined in different models have suggested that they play important roles in cell and cancer biology, since they were identified to be related to important signaling pathways,

SUBMITTER: Dos Santos EC 

PROVIDER: S-EPMC10048635 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature