Qbd-Based Approach to Optimize Niosomal Gel of Levosulpiride for Transdermal Drug Delivery.

ABSTRACT: Poor aqueous solubility besides extensive hepatic first effect significantly decreases the oral absorption of levosulpiride, which in turn minimizes its therapeutic effectiveness. Niosomes have been extensively investigated as a transdermal vesicular nanocarrier to increase the delivery of low permeable compounds into and across the skin. This research work was to design, develop and optimize levosulpiride-loaded niosomal gel and to evaluate its prospects for transdermal delivery. The Box-Behnken design was used to optimize niosomes by analyzing the impact of three factors (cholesterol; X₁, Span 40; X₂, and sonication time; X₃) on the responses (particle size, Y₁, and entrapment efficiency, Y₂). Optimized formulation (NC) was incorpora

SUBMITTER: Alnaim AS 

PROVIDER: S-EPMC10048649 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature