Polymeric Networks Containing Amine Derivatives as Organocatalysts for Knoevenagel Reaction within Continuously Driven Microfluidic Reactors.

ABSTRACT: The Knoevenagel reaction is a classic reaction in organic chemistry for the formation of C-C bonds. In this study, various catalytic monomers for Knoevenagel reactions were synthesized and polymerized via photolithography to form polymeric gel dots with a composition of 90% catalyst, 9% gelling agent and 1% crosslinker. Furthermore, these gel dots were inserted into a microfluidic reactor (MFR) and the conversion of the reaction using gel dots as catalysts in the MFR for 8 h at room temperature was studied. The gel dots containing primary amines showed a better conversion of about 83-90% with aliphatic aldehyde and 86-100% with aromatic aldehyde, compared to the tertiary amines (52-59% with aliphatic aldehyde and 77-93% with aromatic aldehydes) which resembles the reactivity of the amines.

SUBMITTER: Killi N 

PROVIDER: S-EPMC10048661 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature