Moderation of Structural DNA Properties by Coupled Dinucleotide Contents in Eukaryotes.

ABSTRACT: Dinucleotides are known as determinants for various structural and physiochemical properties of DNA and for binding affinities of proteins to DNA. These properties (e.g., stiffness) and bound proteins (e.g., transcription factors) are known to influence important biological functions, such as transcription regulation and 3D chromatin organization. Accordingly, the question arises of how the considerable variations in dinucleotide contents of eukaryotic chromosomes could still provide consistent DNA properties resulting in similar functions and 3D conformations. In this work, we investigate the hypothesis that coupled dinucleotide contents influence DNA properties in opposite directions to moderate each other's influences. Analyzing all 2478 chromosomes of 155 eukaryotic species, considerin

SUBMITTER: Sievers A 

PROVIDER: S-EPMC10048725 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature