^FapydG in the Shadow of ^OXOdG-A Theoretical Study of Clustered DNA Lesions.

ABSTRACT: Genetic information, irrespective of cell type (normal or cancerous), is exposed to a range of harmful factors, which can lead to more than 80 different types of DNA damage. Of these, ^oxoG and ^FapyG have been identified as the most abundant in normoxic and hypoxic conditions, respectively. This article considers d[A^FapyGA^OXOGA]*[TCTCT] (oligo-^FapyG) with clustered DNA lesions (CDLs) containing both the above types of damage at the M06-2x/6-31++G** level of theory in the condensed phase. Furthermore, the electronic properties of oligo-^FapyG were analysed in both equilibrated and non-equilibrated solvation-solute interaction modes. The vertical/adiabatic ionization potential (VIP, AIP) and electron affinity (VEA, AEA) of the i

SUBMITTER: Karwowski BT 

PROVIDER: S-EPMC10049008 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature