Uveal Melanoma Patients Have a Distinct Metabolic Phenotype in Peripheral Blood.

ABSTRACT: Uveal melanomas (UM) are detected earlier. Consequently, tumors are smaller, allowing for novel eye-preserving treatments. This reduces tumor tissue available for genomic profiling. Additionally, these small tumors can be hard to differentiate from nevi, creating the need for minimally invasive detection and prognostication. Metabolites show promise as minimally invasive detection by resembling the biological phenotype. In this pilot study, we determined metabolite patterns in the peripheral blood of UM patients (n = 113) and controls (n = 46) using untargeted metabolomics. Using a random forest classifier (RFC) and leave-one-out cross-validation, we confirmed discriminatory metabolite patterns in UM patients compared to controls with an area under the curve of the receiver operating chara

SUBMITTER: de Bruyn DP 

PROVIDER: S-EPMC10049075 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature