Potential Anti-Candida albicans Mechanism of Trichoderma Acid from Trichoderma spirale.

ABSTRACT: Candida albicans is the main causal pathogen of fungal infections in human beings. Although diverse anti-C. albicans drugs have been explored, the drug resistance and side effects of these drugs are intensifying. Thus, it is urgent to explore new anti-C. albicans compounds from natural products. In this study, we identified trichoderma acid (TA), a compound from Trichoderma spirale with a strong inhibitory effect on C. albicans. Transcriptomic and iTRAQ-based proteomic analyses of TA-treated C. albicans in combination with scanning electronic microscopy and reactive oxygen species (ROS) detection were performed to investigate the potential targets of TA. The most significant differentially expressed genes and proteins after TA treatment were verifi

SUBMITTER: Ye W 

PROVIDER: S-EPMC10049406 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature