Genetic Networks of Alzheimer's Disease, Aging, and Longevity in Humans.

ABSTRACT: Human genomic analysis and genome-wide association studies (GWAS) have identified genes that are risk factors for early and late-onset Alzheimer's disease (AD genes). Although the genetics of aging and longevity have been extensively studied, previous studies have focused on a specific set of genes that have been shown to contribute to or are a risk factor for AD. Thus, the connections among the genes involved in AD, aging, and longevity are not well understood. Here, we identified the genetic interaction networks (referred to as pathways) of aging and longevity within the context of AD by using a gene set enrichment analysis by Reactome that cross-references more than 100 bioinformatic databases to allow interpretation of the biological functions of gene sets through a wide variety of gen

SUBMITTER: Balmorez T 

PROVIDER: S-EPMC10049434 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature