Advances in 3D Organoid Models for Stem Cell-Based Cardiac Regeneration.

ABSTRACT: The adult human heart cannot regain complete cardiac function following tissue injury, making cardiac regeneration a current clinical unmet need. There are a number of clinical procedures aimed at reducing ischemic damage following injury; however, it has not yet been possible to stimulate adult cardiomyocytes to recover and proliferate. The emergence of pluripotent stem cell technologies and 3D culture systems has revolutionized the field. Specifically, 3D culture systems have enhanced precision medicine through obtaining a more accurate human microenvironmental condition to model disease and/or drug interactions in vitro. In this study, we cover current advances and limitations in stem cell-based cardiac regenerative medicine. Specifically, we discuss the clinical implementation and limi

SUBMITTER: Martin M 

PROVIDER: S-EPMC10049446 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature