The Molecular Mechanism of Polyphenols in the Regulation of Ageing Hallmarks.

ABSTRACT: Ageing is a complex process characterized mainly by a decline in the function of cells, tissues, and organs, resulting in an increased risk of mortality. This process involves several changes, described as hallmarks of ageing, which include genomic instability, telomere attrition, epigenetic changes, loss of proteostasis, dysregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell depletion, and altered intracellular communication. The determining role that environmental factors such as diet and lifestyle play on health, life expectancy, and susceptibility to diseases, including cancer and neurodegenerative diseases, is wellestablished. In view of the growing interest in the beneficial effects of phytochemicals in the prevention of chronic diseases, several stu

SUBMITTER: Pereira QC 

PROVIDER: S-EPMC10049696 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature