FTIR Analysis of Renal Tissue for the Assessment of Hypertensive Organ Damage and proANP_31-67 Treatment.

ABSTRACT: The kidneys are one of the main end organs targeted by hypertensive disease. Although the central role of the kidneys in the regulation of high blood pressure has been long recognized, the detailed mechanisms behind the pathophysiology of renal damage in hypertension remain a matter of investigation. Early renal biochemical alterations due to salt-induced hypertension in Dahl/salt-sensitive rats were monitored by Fourier-Transform Infrared (FTIR) micro-imaging. Furthermore, FTIR was used to investigate the effects of proANP_31-67, a linear fragment of pro-atrial natriuretic peptide, on the renal tissue of hypertensive rats. Different hypertension-induced alterations were detected in the renal parenchyma and blood vessels by the combination of FTIR imaging and principal component

SUBMITTER: Pioppi L 

PROVIDER: S-EPMC10049716 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature