Biomarker-Development Proteomics in Kidney Transplantation: An Updated Review.

ABSTRACT: Kidney transplantation (KT) is the optimal therapeutic strategy for patients with end-stage renal disease. The key to post-transplantation management is careful surveillance of allograft function. Kidney injury may occur from several different causes that require different patient management approaches. However, routine clinical monitoring has several limitations and detects alterations only at a later stage of graft damage. Accurate new noninvasive biomarker molecules are clearly needed for continuous monitoring after KT in the hope that early diagnosis of allograft dysfunction will lead to an improvement in the clinical outcome. The advent of "omics sciences", and in particular of proteomic technologies, has revolutionized medical research. Proteomic technologies allow us to achieve the

SUBMITTER: Sirolli V 

PROVIDER: S-EPMC10049725 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature