Myeloid-derived suppressor cells: key immunosuppressive regulators and therapeutic targets in hematological malignancies.

ABSTRACT: The immunosuppressive tumor microenvironment (TME) supports the development of tumors and limits tumor immunotherapy, including hematological malignancies. Hematological malignancies remain a major public health issue with high morbidity and mortality worldwide. As an important component of immunosuppressive regulators, the phenotypic characteristics and prognostic value of myeloid-derived suppressor cells (MDSCs) have received much attention. A variety of MDSC-targeting therapeutic approaches have produced encouraging outcomes. However, the use of various MDSC-targeted treatment strategies in hematologic malignancies is still difficult due to the heterogeneity of hematologic malignancies and the complexity of the immune system. In this review, we summarize the biological functions of MDSC

SUBMITTER: Wang S 

PROVIDER: S-EPMC10049909 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature