Systematic review of the management of brain metastases from hormone receptor positive breast cancer.

ABSTRACT:

Introduction

Brain metastases are a common cause of morbidity and mortality in patients with breast cancer. Local central nervous system (CNS) directed therapies are usually the first line treatment for breast cancer brain metastases (BCBM), but those must be followed by systemic therapies to achieve long-term benefit. Systemic therapy for hormone receptor (HR⁺) breast cancer has evolved in the last 10 years, but their role when brain metastases occur is uncertain.

Methods

We performed a systematic review of the literature focused on management of HR⁺ BCBM by searching Medline/PubMed, EBSCO, and Cochrane databases. The PRISMA guidelines were used for systematic review.

Results

Out of 807 articles identified, 98 fulfilled the inclusion criteria in

SUBMITTER: Jusino S 

PROVIDER: S-EPMC10049940 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature