Meta-analytic connectivity modelling of functional magnetic resonance imaging studies in autism spectrum disorders.

ABSTRACT: Social and non-social deficits in autism spectrum disorders (ASD) persist into adulthood and may share common regions of aberrant neural activations. The current meta-analysis investigated activation differences between ASD and neurotypical controls irrespective of task type. Activation likelihood estimation meta-analyses were performed to examine consistent hypo-activated and/or hyper-activated regions for all tasks combined, and for social and non-social tasks separately; meta-analytic connectivity modelling and behavioral/paradigm analyses were performed to examine co-activated regions and associated behaviors. One hundred studies (mean age range = 18-41 years) were included. For all tasks combined, the ASD group showed significant (p < .05) hypo-activation in one cluster around the lef

SUBMITTER: Goodwill AM 

PROVIDER: S-EPMC10049951 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature