Prognostic impact of extracranial disease control in HER2+ breast cancer-related brain metastases.

ABSTRACT:

Background

Brain metastases (BM) are common among HER2+ breast cancer (BC) and prognostic stratification is crucial for optimal management. BC-GPA score and subsequent refinements (modified-GPA, updated-GPA) recapitulate prognostic factors. Since none of these indexes includes extracranial disease control, we evaluated its prognostic value in HER2+ BCBM.

Methods

Patients diagnosed with HER2+ BCBM at Istituto Oncologico Veneto-Padova (2002-2021) and Montpellier Cancer Institute (2001-2015) were included as exploratory and validation cohorts, respectively. Extracranial disease control at BM diagnosis (no disease/stable disease/response vs. progressive disease) was evaluated.

Results

In the exploratory cohort of 113 patients (median OS 12.2 months), extracranial control

SUBMITTER: Bottosso M 

PROVIDER: S-EPMC10049979 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature