Dataset Information

Dietary patterns related to biological mechanisms and survival after breast cancer diagnosis: results from a cohort study.

ABSTRACT:

Background

Inflammatory, insulin and oestrogenic pathways have been linked to breast cancer (BC). We aimed to examine the relationship between pre-diagnostic dietary patterns related to these mechanisms and BC survival.

Methods

The diabetes risk reduction diet (DRRD), inflammatory score of diet (ISD) and oestrogen-related dietary pattern (ERDP) were calculated using dietary data from the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Cox proportional hazards models were used to assess associations between dietary patterns and overall mortality and competing risk models for associations with BC-specific mortality.

Results

We included 13,270 BC cases with a mean follow-up after diagnosis of 8.6 years, representing 2340 total deaths, including 1475 BC deaths. Higher adherence to the DRRD score was associated with lower overall mortality (HR_1-SD 0.92; 95%CI 0.87-0.96). Greater adherence to pro-inflammatory diets was borderline associated with 6% higher mortality HR_1-SD 1.06; 95%CI 1.00-1.12. No significant association with the oestrogen-related dietary pattern was observed. None of the dietary patterns were associated with BC-specific mortality.

Conclusions

Greater adherence to an anti-diabetic and anti-inflammatory diet prior to diagnosis is associated with lower overall mortality among BC survivors. Long-term adherence to these dietary patterns could be a means to improve the prognosis of BC survivors.

SUBMITTER: Castro-Espin C

PROVIDER: S-EPMC10050013 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature

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Publications

Dietary patterns related to biological mechanisms and survival after breast cancer diagnosis: results from a cohort study.

Castro-Espin Carlota C Bonet Catalina C Crous-Bou Marta M Katzke Verena V Le Cornet Charlotte C Jannasch Franziska F Schulze Matthias B MB Olsen Anja A Tjønneland Anne A Dahm Christina C CC Antoniussen Christian S CS Sánchez Maria Jose MJ Amiano Pilar P Chirlaque María Dolores MD Guevara Marcela M Agnoli Claudia C Tumino Rosario R Sacerdote Carlotta C De Magistris Maria Santucci MS Sund Malin M Bodén Stina S Jensen Torill Enget TE Olsen Karina Standahl KS Skeie Guri G Gunter Marc J MJ Rinaldi Sabina S Gonzalez-Gil Esther M EM Weiderpass Elisabete E Christakoudi Sofia S Heath Alicia K AK Dossus Laure L Agudo Antonio A

British journal of cancer 20230203 7

<h4>Background</h4>Inflammatory, insulin and oestrogenic pathways have been linked to breast cancer (BC). We aimed to examine the relationship between pre-diagnostic dietary patterns related to these mechanisms and BC survival.<h4>Methods</h4>The diabetes risk reduction diet (DRRD), inflammatory score of diet (ISD) and oestrogen-related dietary pattern (ERDP) were calculated using dietary data from the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Cox proportional ha ...[more]

PMID: 36737658

Similar Datasets

Project description:BackgroundThe Mediterranean diet has been associated with lower risk of breast cancer (BC) but evidence from prospective studies on the role of Mediterranean diet on BC survival remains sparse and conflicting. We aimed to investigate whether adherence to Mediterranean diet prior to diagnosis is associated with overall and BC-specific mortality.MethodsA total of 13,270 incident breast cancer cases were identified from an initial sample of 318,686 women in 9 countries from the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Adherence to Mediterranean diet was estimated through the adapted relative Mediterranean diet (arMED), a 16-point score that includes 8 key components of the Mediterranean diet and excludes alcohol. The degree of adherence to arMED was classified as low (score 0-5), medium (score 6-8), and high (score 9-16). Multivariable Cox proportional hazards models were used to analyze the association between the arMED score and overall mortality, and Fine-Gray competing risks models were applied for BC-specific mortality.ResultsAfter a mean follow-up of 8.6 years from diagnosis, 2340 women died, including 1475 from breast cancer. Among all BC survivors, low compared to medium adherence to arMED score was associated with a 13% higher risk of all-cause mortality (HR 1.13, 95%CI 1.01-1.26). High compared to medium adherence to arMED showed a non-statistically significant association (HR 0.94; 95% CI 0.84-1.05). With no statistically significant departures from linearity, on a continuous scale, a 3-unit increase in the arMED score was associated with an 8% reduced risk of overall mortality (HR3-unit 0.92, 95% CI: 0.87-0.97). This result sustained when restricted to postmenopausal women and was stronger among metastatic BC cases (HR3-unit 0.81, 95% CI: 0.72-0.91).ConclusionsConsuming a Mediterranean diet before BC diagnosis may improve long-term prognosis, particularly after menopause and in cases of metastatic breast cancer. Well-designed dietary interventions are needed to confirm these findings and define specific dietary recommendations.

Dataset Information

Dietary patterns related to biological mechanisms and survival after breast cancer diagnosis: results from a cohort study.

Background

Methods

Results

Conclusions

Publications

Dietary patterns related to biological mechanisms and survival after breast cancer diagnosis: results from a cohort study.

Similar Datasets

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