Interstitial photodynamic therapy for newly diagnosed glioblastoma.

ABSTRACT:

Purpose

Innovative, efficient treatments are desperately needed for people with glioblastoma (GBM).

Methods

Sixteen patients (median age 65.8 years) with newly diagnosed, small-sized, not safely resectable supratentorial GBM underwent interstitial photodynamic therapy (iPDT) as upfront eradicating local therapy followed by standard chemoradiation. 5-aminolevulinic acid (5-ALA) induced protoporphyrin IX was used as the photosensitizer. The tumors were irradiated with light at 635 nm wavelength via stereotactically implanted cylindrical diffuser fibers. Outcome after iPDT was retrospectively compared with a positively-selected in-house patient cohort (n = 110) who underwent complete tumor resection followed by chemoradiation.

Results

Median progression-free survival (PF

SUBMITTER: Quach S 

PROVIDER: S-EPMC10050060 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature