Nuclear PD-L1 promotes EGR1-mediated angiogenesis and accelerates tumorigenesis.

ABSTRACT: Targeting programmed cell death protein ligand 1 (PD-L1) remains one of the most essential immunotherapies in cancer^1,2. PD-L1 has been detected in the nucleus in multiple malignancies, playing an oncogenic role independent of immune checkpoint regulation^3-5. Howbeit, the regulatory function of nuclear PD-L1 (nPD-L1) remains to be fully understood. Here, we report that nPD-L1 is an endogenous accelerator for cancer angiogenesis. First, we found that an abundant proportion of PD-L1 was distributed within the nucleus of uveal melanoma samples, which is associated with an unfavorable outcome. Moreover, the capacity of promoting angiogenesis was largely attenuated in the nPD-L1-deficient cells both in vivo and in vitro. Mechanistically, nPD-L1 facilitates p-STAT3 binding

SUBMITTER: Yu J 

PROVIDER: S-EPMC10050073 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature