A Genomic Risk Score Identifies Individuals at High Risk for Intracerebral Hemorrhage.

ABSTRACT:

Background

Intracerebral hemorrhage (ICH) has an estimated heritability of 29%. We developed a genomic risk score for ICH and determined its predictive power in comparison to standard clinical risk factors.

Methods

We combined genome-wide association data from individuals of European ancestry for ICH and related traits in a meta-genomic risk score ([metaGRS]; 2.6 million variants). We tested associations with ICH and its predictive performance in addition to clinical risk factors in a held-out validation dataset (842 cases and 796 controls). We tested associations with risk of incident ICH in the population-based UK Biobank cohort (486 784 individuals, 1526 events, median follow-up 11.3 years).

Results

One SD increment in the metaGRS was significantly associated with

SUBMITTER: Myserlis EP 

PROVIDER: S-EPMC10050100 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature