MmCMS: mouse models' consensus molecular subtypes of colorectal cancer.

ABSTRACT:

Background

Colorectal cancer (CRC) primary tumours are molecularly classified into four consensus molecular subtypes (CMS1-4). Genetically engineered mouse models aim to faithfully mimic the complexity of human cancers and, when appropriately aligned, represent ideal pre-clinical systems to test new drug treatments. Despite its importance, dual-species classification has been limited by the lack of a reliable approach. Here we utilise, develop and test a set of options for human-to-mouse CMS classifications of CRC tissue.

Methods

Using transcriptional data from established collections of CRC tumours, including human (TCGA cohort; n = 577) and mouse (n = 57 across n = 8 genotypes) tumours with combinations of random forest and nearest template prediction algorithms, alongside

SUBMITTER: Amirkhah R 

PROVIDER: S-EPMC10050155 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature