The role of maternal age & birth order on the development of unilateral and bilateral retinoblastoma: a multicentre study.

ABSTRACT:

Background/objectives

Retinoblastoma is a common childhood intraocular malignancy, the bilateral form of which most commonly results from a de novo germline pathogenic variant in the RB1 gene. Both advanced maternal age and decreasing birth order are known to increase the risk of de novo germline pathogenic variants, while the influence of national wealth is understudied. This cohort study aimed to retrospectively observe whether these factors influence the ratio of bilateral retinoblastoma cases compared to unilateral retinoblastoma, thereby inferring an influence on the development of de novo germline pathogenic variants in RB1.

Subjects/methods

Data from 688 patients from 11 centres in 10 countries were analysed using a series of statistical methods.

Results

No ass

SUBMITTER: Lloyd P 

PROVIDER: S-EPMC10050160 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature