Evaluation of piperine analogs against prostate cancer targeting AKT1 kinase domain through network pharmacological analysis.

ABSTRACT: Prostate cancer is the second most fatal malignancy in men after lung cancer, and the fifth leading cause of death. Piperine has been utilized for its therapeutic effects since the time of Ayurveda. According to traditional Chinese medicine, piperine has a wide variety of pharmacological effects, including anti-inflammatory, anti-cancer, and immune-regulating properties. Based on the previous study, Akt1 (protein kinase B) is one of the targets of piperine, it belongs to the group of oncogenes and the mechanism of the Akt1 is an interesting approach for anticancer drug design. From the peer-reviewed literature, five piperine analogs were identified altogether, and a combinatorial collection was formed. However, may not be entirely clear how piperine analogs work to prevent prostate cancer.

SUBMITTER: Prakash N 

PROVIDER: S-EPMC10050269 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature