Dataset Information

Children with chronic myeloid leukaemia treated with front-line imatinib have a slower molecular response and comparable survival compared with adults: a multicenter experience in Taiwan.

ABSTRACT:

Background

The direct comparison of molecular responses of front-line imatinib (IM) monitored at the same laboratory between children and adults with chronic phase (CP) of chronic myeloid leukaemia (CML) had not been reported. In this multicenter study, we compared the landmark molecular responses and outcomes of paediatric and adult CML-CP cohorts treated with front-line IM in whom the BCR::ABL1 transcript levels were monitored at the same accredited laboratory in Taiwan.

Methods

Between June 2004 and July 2020, 55 newly diagnosed paediatric and 782 adult CML-CP patients, with molecular diagnosis and monitoring at the same reference laboratory in Taiwan, were enrolled. The criteria of 2020 European LeukemiaNet were applied to evaluate the molecular responses.

Results

By year 5, the cumulative incidences of IS <1%, MMR, MR^4.0 and MR^4.5 of paediatric patients were all significantly lower than those of adult patients (58 vs 75%, 48 vs 66%, 25 vs 44%, 16 vs 34%, respectively). The 10-year progression-free survival (PFS) (90%) and overall survival (OS) (94%) of paediatric patients did not differ from those (92%) of adult patients.

Conclusions

We demonstrated the paediatric cohort had slower molecular responses to front-line IM and similar outcomes in 10-year PFS and OS in real-world practice.

SUBMITTER: Liu HC

PROVIDER: S-EPMC10050312 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature

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Publications

Children with chronic myeloid leukaemia treated with front-line imatinib have a slower molecular response and comparable survival compared with adults: a multicenter experience in Taiwan.

Liu Hsi-Che HC Kuo Ming-Chung MC Wu Kang-Hsi KH Chen Tsai-Yun TY Chen Jiann-Shiuh JS Wang Ming-Chung MC Lin Tung-Liang TL Yang YoungSen Y Ma Ming-Chun MC Wang Po-Nan PN Sheen Jiunn-Ming JM Wang Shih-Chung SC Chen Shih-Hsiang SH Jaing Tang-Her TH Cheng Chao-Neng CN Yeh Ting-Chi TC Lin Tung-Huei TH Shih Lee-Yung LY

British journal of cancer 20230130 7

<h4>Background</h4>The direct comparison of molecular responses of front-line imatinib (IM) monitored at the same laboratory between children and adults with chronic phase (CP) of chronic myeloid leukaemia (CML) had not been reported. In this multicenter study, we compared the landmark molecular responses and outcomes of paediatric and adult CML-CP cohorts treated with front-line IM in whom the BCR::ABL1 transcript levels were monitored at the same accredited laboratory in Taiwan.<h4>Methods</h4 ...[more]

PMID: 36717672

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Dataset Information

Children with chronic myeloid leukaemia treated with front-line imatinib have a slower molecular response and comparable survival compared with adults: a multicenter experience in Taiwan.

Background

Methods

Results

Conclusions

Publications

Children with chronic myeloid leukaemia treated with front-line imatinib have a slower molecular response and comparable survival compared with adults: a multicenter experience in Taiwan.

Similar Datasets

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