TREM2 deficiency in microglia accelerates photoreceptor cell death and immune cell infiltration following retinal detachment.

ABSTRACT: Retinal detachment (RD) occurs in several major retinal conditions and often causes irreversible vision loss due to photoreceptor cell death. Retinal residential microglial cells are activated following RD and participate in photoreceptor cell death via direct phagocytosis and the regulation of inflammatory responses. Triggering receptor expressed on myeloid cells 2 (TREM2) is an innate immune receptor exclusively expressed on microglial cells in the retina, and has been reported to affect microglial cell homeostasis, phagocytosis and inflammatory responses in the brain. In this study, increased expression of multiple cytokines and chemokines in the neural retina was observed starting at 3 h following RD. Trem2 knockout (Trem2^-/-) mice exhibited significantly more photoreceptor

SUBMITTER: Zhou W 

PROVIDER: S-EPMC10050330 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature