Severe nephrotic syndrome and early end-stage diabetic kidney disease in ABCC8-MODY12: A case report.

ABSTRACT: A 24-year-old man with diabetes mellitus presented with advanced kidney disease and severe proteinuria. Genetic testing revealed ABCC8-MODY12 (OMIM 600509), and a kidney biopsy showed nodular glomerulosclerosis. He commenced dialysis shortly thereafter, and glycemic control improved on treatment with a sulfonylurea. Diabetic end-stage kidney disease in patients with ABCC8-MODY12 has not been reported until now. Thus, our case highlights the risk for early-onset and severe diabetic kidney disease in patients with ABCC8-MODY12 and the importance of timely genetic diagnosis in unusual cases of diabetes to allow for proper treatment and prevention of late sequelae of diabetes.

SUBMITTER: Schmidt SH 

PROVIDER: S-EPMC10050546 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature