Parasitic nematode secreted phospholipase A₂ suppresses cellular and humoral immunity by targeting hemocytes in Drosophila melanogaster.

ABSTRACT: A key aspect of parasitic nematode infection is the nematodes' ability to evade and/or suppress host immunity. This immunomodulatory ability is likely driven by the release of hundreds of excretory/secretory proteins (ESPs) during infection. While ESPs have been shown to display immunosuppressive effects on various hosts, our understanding of the molecular interactions between individual proteins released and host immunity requires further study. We have recently identified a secreted phospholipase A2 (sPLA₂) released from the entomopathogenic nematode (EPN) Steinernema carpocapsae we have named Sc-sPLA₂. We report that Sc-sPLA₂ increased mortality of Drosophila melanogaster infected with Streptococcus pneumoniae and promoted increased

SUBMITTER: Parks SC 

PROVIDER: S-EPMC10050561 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature