Hippocampal oscillatory dynamics in freely behaving rats during exploration of social and non-social stimuli.

ABSTRACT: Hippocampal CA2 supports social memory and encodes information about social experiences. Our previous study showed that CA2 place cells responded specifically to social stimuli (Nat Commun, (Alexander et al. 2016)). In addition, a prior study showed that activation of CA2 induces slow gamma rhythms (~ 25-55 Hz) in the hippocampus (Elife, (Alexander 2018)). Together, these results raise the question of whether slow gamma rhythms coordinate CA2 activity during social information processing. We hypothesized that slow gamma would be associated with transmission of social memories from CA2 to CA1, perhaps to integrate information across regions or promote social memory retrieval. We recorded local field potentials from hippocampal subfields CA1, CA2, and CA3 of 4 rats performing a social explor

SUBMITTER: Zhu N 

PROVIDER: S-EPMC10050611 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature