The outcome of acute kidney injury substages based on urinary cystatin C in critically ill children.

ABSTRACT:

Background

The concept of acute kidney injury (AKI) substages has been recommended to better phenotype AKI and identify high-risk patient groups and therefore improve the diagnostic accuracy of AKI. However, there remains a gap between the recommendation and the clinical application. The study aimed to explore the incidence of AKI substages based on a sensitive AKI biomarker of urinary cystatin C (uCysC), and to determine whether AKI substages were relevant with respect to outcome in critically ill children.

Results

The multicenter cohort study enrolled 793 children in pediatric intensive care unit (PICU) of four tertiary hospitals in China. Children were classified as non-AKI, sub-AKI and AKI substages A and B according to uCysC level at PICU admission. Sub-AKI was defined

SUBMITTER: Chen J 

PROVIDER: S-EPMC10050666 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature