Establishing a human bone marrow single cell reference atlas to study ageing and diseases.

ABSTRACT:

Introduction

Ageing in the human bone marrow is associated with immune function decline that results in the elderly being vulnerable to illnesses. A comprehensive healthy bone marrow consensus atlas can serve as a reference to study the immunological changes associated with ageing, and to identify and study abnormal cell states.

Methods

We collected publicly available single cell transcriptomic data of 145 healthy samples encompassing a wide spectrum of ages ranging from 2 to 84 years old to construct our human bone marrow atlas. The final atlas has 673,750 cells and 54 annotated cell types.

Results

We first characterised the changes in cell population sizes with respect to age and the corresponding changes in gene expression and pathways. Overall, we found significan

SUBMITTER: Lee NYS 

PROVIDER: S-EPMC10050687 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature