An inverse causal association between genetically predicted vitamin D and chronic obstructive pulmonary disease risk.

ABSTRACT:

Aim

Observational studies have reported that levels of vitamin D were associated with the incidence of chronic obstructive pulmonary disease (COPD), but the relationship between them may have been confounded in previous studies. In this study, we aimed to determine the relationship between the levels of 25-hydroxyvitamin D (25OHD) and the risk of COPD by two-sample Mendelian randomization (MR) analysis.

Methods

Summary statistics for 25OHD and COPD in this study were obtained from the EBI (n = 496,946) consortium and Finn (n = 187,754) consortium. MR was adopted to explore the effect of the genetically predicted levels of 25OHD on the risk of COPD. Based on three assumptions of MR analysis, inverse variance weighting was used as the main analysis. To make our r

SUBMITTER: Lu K 

PROVIDER: S-EPMC10050703 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature