The role of plasma cortisol in dementia, epilepsy, and multiple sclerosis: A Mendelian randomization study.

ABSTRACT:

Background

Many clinical studies have shown a correlation between plasma cortisol and neurological disorders. This study explored the causal relationship between plasma cortisol and dementia, epilepsy and multiple sclerosis based on Mendelian randomization (MR) method.

Methods

Data were taken from the summary statistics of a genome-wide association study, FinnGen consortium and United Kingdom Biobank. Dementia, epilepsy, and multiple sclerosis were used as outcomes, and genetic variants associated with plasma cortisol were used as instrumental variables. The main analysis was performed using the inverse variance weighted method, and the results were assessed according to the odds ratio (OR) and 95% confidence interval. Heterogeneity tests, pleiotropy tests, and leave-one-out

SUBMITTER: Li H 

PROVIDER: S-EPMC10050717 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature