Cortisol and periodontitis: Prospective observational and Mendelian randomization studies.

ABSTRACT:

Purpose

Cortisol has obesogenic, hyperglycemic and immunomodulating effects. Preclinical and observational research suggested that it is associated with periodontitis but the evidence for potential causality in humans is sparse. We triangulated results from prospective observational and Mendelian randomization (MR) analyses to further explore this.

Methods

Using pooled data from 3,388 participants of two population cohort studies embedded in the Study of Health in Pomerania (SHIP) project, we associated serum cortisol levels with periodontal outcomes measured after a median follow-up time of 6.9 years, adjusting for confounding and selection bias using propensity score weighting and multiple imputation. We further examined the effect of genetically proxied plasma morning cor

SUBMITTER: Baumeister SE 

PROVIDER: S-EPMC10050732 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature