Assessment of local and systemic signature of eosinophilic esophagitis (EoE) in children through multi-omics approaches.

ABSTRACT:

Background

Eosinophilic oesophagitis (EoE) is a chronic food allergic disorder limited to oesophageal mucosa whose pathogenesis is still only partially understood. Moreover, its diagnosis and follow-up need repeated endoscopies due to absence of non-invasive validated biomarkers. In the present study, we aimed to deeply describe local immunological and molecular components of EoE in well-phenotyped children, and to identify potential circulating EoE-biomarkers.

Methods

Blood and oesophageal biopsies were collected simultaneously from French children with EoE (n=17) and from control subjects (n=15). Untargeted transcriptomics analysis was performed on mRNA extracted from biopsies using microarrays. In parallel, we performed a comprehensive analysis of immune components on bot

SUBMITTER: Adel-Patient K 

PROVIDER: S-EPMC10050742 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature