Causal relationship between polycystic ovary syndrome and chronic kidney disease: A Mendelian randomization study.

ABSTRACT:

Objective

Polycystic ovary syndrome is one of the most common endocrine disorders among women of childbearing age. The relationship between polycystic ovary syndrome and chronic kidney disease remains unclear and controversial. In this study, we investigated the causal role of polycystic ovary syndrome in the development of chronic kidney disease using the two-sample Mendelian randomization method.

Methods

Public shared summary-level data was acquired from European-ancestry genome wide association studies. We finally obtained 12 single nucleotide polymorphisms as instrumental variables, which were associated with polycystic ovary syndrome in European at genome-wide significance (P < 5 × 10^-8). Inverse-variance weighted method was employed in the Mendelian randomiz

SUBMITTER: Du Y 

PROVIDER: S-EPMC10050750 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature