Transcriptome landscape comparison of periodontium in developmental and renewal stages.

ABSTRACT:

Objectives

Periodontium regeneration remains a significant challenge in clinics and research, and it is essential to understand the stage-specific biological process in situ. However, differing findings have been reported, and the mechanism has yet to be elucidated. The periodontium of adult mice molars is considered to be stable remodeling tissue. At the same time, the continuously growing incisors and the developing dental follicle (DF) of postnatal mice highly represent fast remodeling tissue. In this study, we attempted to explore different clues of temporal and spatial comparisons to provide improved references for periodontal regeneration.

Methods

Periodontal tissues from the developing periodontium (DeP) of postnatal mice, and continuously growing periodontium (CgP) a

SUBMITTER: Deng Y 

PROVIDER: S-EPMC10050752 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature